At Fontan 3, VO 2 at VAT was better preserved than peak VO 2 across all tertiles, with higher rates of overweight and obesity in the lower performing group (p = 0.001). Percent-predicted VO 2 at VAT decreased by 0.8 ± 2.6% per year ( p < 0.001). Paired data at the ventilatory anaerobic threshold (VO 2 at VAT) were available for 196 VAT data at Fontan 3 were available for 311. Female gender was more prevalent in the highest performing tertile ( p = 0.004). At Fontan 3, the lowest performing peak VO 2 tertile had the highest rate of overweight and obesity (p < 0.001). Percent-predicted peak VO 2 declined by 0.8 ± 1.7% per year (p < 0.001). Paired measurements of peak oxygen consumption (peak VO 2) were available for 95 peak exercise data at Fontan 3 were available for 275. There were 336 participants in Fontan 3, mean age 23.2 years. Associations between these outcomes and patient characteristics were analyzed. Annualized change was evaluated at maximal and submaximal exercise. Ramp cycle ergometry was re-performed in consented participants who had originally participated in the Pediatric Heart Network’s Fontan cross-sectional study. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Impaired exercise following Fontan is a surrogate of morbidity.
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